Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.
Identifieur interne : 000029 ( Main/Exploration ); précédent : 000028; suivant : 000030Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.
Auteurs : Denise Lacerda [Brésil] ; Patrick Türck [Brésil] ; Cristina Campos-Carraro [Brésil] ; Alexandre Hickmann [Brésil] ; Vanessa Ortiz [Brésil] ; Sara Bianchi [Brésil] ; Adriane Bell Klein [Brésil] ; Alexandre Luz De Castro [Brésil] ; Valquiria Linck Bassani [Brésil] ; Alex Sander Da Rosa Araujo [Brésil]Source :
- Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [ 1715-5320 ] ; 2020.
Abstract
This study explored the effect of pterostilbene (PTS) complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on right heart function, glutathione and glutaredoxin systems, and the expression of redox-sensitive proteins involved with regulation calcium levels in the experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). After 7 days of PAH induction, rats received daily doses of the PTS:HPβCD complex (corresponding to 25, 50, or 100 mg·kg-1 of PTS) or vehicle (control group, CTR0) (an aqueous solution containing HPβCD; CTR0 and MCT0 (MCT group that did not receive PTS treatment)) via oral administration for 2 weeks. The results showed that the PTS:HPβCD complex increased the content of reduced glutathione and the activity of glutathione-S-transferase and glutaredoxin in the right ventricle (RV) of MCT-treated rats in a dose-dependent manner. Additionally, at higher doses, it also prevented the reduction of stroke volume and cardiac output, prevented myocardial performance index (MPI) increase, reduced lipoperoxidation, reduced total phospholamban, and increased the expression of sarcoplasmic reticulum calcium ATPase in the RV of MCT-treated rats. These results demonstrate that the PTS:HPβCD complex has a dose-dependent antioxidant mechanism that results in improved cardiac function in experimental right heart failure. Our results open a field of possibilities to PTS administration as new therapeutic approach to conventional therapy for right ventricular dysfunction. Novelty Pterostilbene complexed with hydroxypropyl-β-cyclodextrin could be a new therapeutic approach. Pterostilbene complexed with hydroxypropyl-β-cyclodextrin reestablishes redox homeostasis through glutathione metabolism modulation, leading to an improved MPI in pulmonary arterial hypertension-provoked right heart failure.
DOI: 10.1139/apnm-2019-0864
PubMed: 32191845
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.</title><author><name sortKey="Lacerda, Denise" sort="Lacerda, Denise" uniqKey="Lacerda D" first="Denise" last="Lacerda">Denise Lacerda</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Turck, Patrick" sort="Turck, Patrick" uniqKey="Turck P" first="Patrick" last="Türck">Patrick Türck</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Campos Carraro, Cristina" sort="Campos Carraro, Cristina" uniqKey="Campos Carraro C" first="Cristina" last="Campos-Carraro">Cristina Campos-Carraro</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Hickmann, Alexandre" sort="Hickmann, Alexandre" uniqKey="Hickmann A" first="Alexandre" last="Hickmann">Alexandre Hickmann</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Ortiz, Vanessa" sort="Ortiz, Vanessa" uniqKey="Ortiz V" first="Vanessa" last="Ortiz">Vanessa Ortiz</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bianchi, Sara" sort="Bianchi, Sara" uniqKey="Bianchi S" first="Sara" last="Bianchi">Sara Bianchi</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bell Klein, Adriane" sort="Bell Klein, Adriane" uniqKey="Bell Klein A" first="Adriane" last="Bell Klein">Adriane Bell Klein</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="De Castro, Alexandre Luz" sort="De Castro, Alexandre Luz" uniqKey="De Castro A" first="Alexandre Luz" last="De Castro">Alexandre Luz De Castro</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bassani, Valquiria Linck" sort="Bassani, Valquiria Linck" uniqKey="Bassani V" first="Valquiria Linck" last="Bassani">Valquiria Linck Bassani</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Araujo, Alex Sander Da Rosa" sort="Araujo, Alex Sander Da Rosa" uniqKey="Araujo A" first="Alex Sander Da Rosa" last="Araujo">Alex Sander Da Rosa Araujo</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32191845</idno><idno type="pmid">32191845</idno><idno type="doi">10.1139/apnm-2019-0864</idno><idno type="wicri:Area/Main/Corpus">000069</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000069</idno><idno type="wicri:Area/Main/Curation">000069</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000069</idno><idno type="wicri:Area/Main/Exploration">000069</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.</title><author><name sortKey="Lacerda, Denise" sort="Lacerda, Denise" uniqKey="Lacerda D" first="Denise" last="Lacerda">Denise Lacerda</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Turck, Patrick" sort="Turck, Patrick" uniqKey="Turck P" first="Patrick" last="Türck">Patrick Türck</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Campos Carraro, Cristina" sort="Campos Carraro, Cristina" uniqKey="Campos Carraro C" first="Cristina" last="Campos-Carraro">Cristina Campos-Carraro</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Hickmann, Alexandre" sort="Hickmann, Alexandre" uniqKey="Hickmann A" first="Alexandre" last="Hickmann">Alexandre Hickmann</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Ortiz, Vanessa" sort="Ortiz, Vanessa" uniqKey="Ortiz V" first="Vanessa" last="Ortiz">Vanessa Ortiz</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bianchi, Sara" sort="Bianchi, Sara" uniqKey="Bianchi S" first="Sara" last="Bianchi">Sara Bianchi</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bell Klein, Adriane" sort="Bell Klein, Adriane" uniqKey="Bell Klein A" first="Adriane" last="Bell Klein">Adriane Bell Klein</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="De Castro, Alexandre Luz" sort="De Castro, Alexandre Luz" uniqKey="De Castro A" first="Alexandre Luz" last="De Castro">Alexandre Luz De Castro</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Bassani, Valquiria Linck" sort="Bassani, Valquiria Linck" uniqKey="Bassani V" first="Valquiria Linck" last="Bassani">Valquiria Linck Bassani</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Araujo, Alex Sander Da Rosa" sort="Araujo, Alex Sander Da Rosa" uniqKey="Araujo A" first="Alex Sander Da Rosa" last="Araujo">Alex Sander Da Rosa Araujo</name><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170</wicri:regionArea><orgName type="university">Université fédérale du Rio Grande do Sul</orgName><placeName><settlement type="city">Porto Alegre</settlement><region type="state">Rio Grande do Sul</region></placeName></affiliation></author></analytic><series><title level="j">Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme</title><idno type="eISSN">1715-5320</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study explored the effect of pterostilbene (PTS) complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on right heart function, glutathione and glutaredoxin systems, and the expression of redox-sensitive proteins involved with regulation calcium levels in the experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). After 7 days of PAH induction, rats received daily doses of the PTS:HPβCD complex (corresponding to 25, 50, or 100 mg·kg<sup>-1</sup> of PTS) or vehicle (control group, CTR0) (an aqueous solution containing HPβCD; CTR0 and MCT0 (MCT group that did not receive PTS treatment)) via oral administration for 2 weeks. The results showed that the PTS:HPβCD complex increased the content of reduced glutathione and the activity of glutathione-<i>S</i>-transferase and glutaredoxin in the right ventricle (RV) of MCT-treated rats in a dose-dependent manner. Additionally, at higher doses, it also prevented the reduction of stroke volume and cardiac output, prevented myocardial performance index (MPI) increase, reduced lipoperoxidation, reduced total phospholamban, and increased the expression of sarcoplasmic reticulum calcium ATPase in the RV of MCT-treated rats. These results demonstrate that the PTS:HPβCD complex has a dose-dependent antioxidant mechanism that results in improved cardiac function in experimental right heart failure. Our results open a field of possibilities to PTS administration as new therapeutic approach to conventional therapy for right ventricular dysfunction. <b>Novelty</b> Pterostilbene complexed with hydroxypropyl-β-cyclodextrin could be a new therapeutic approach. Pterostilbene complexed with hydroxypropyl-β-cyclodextrin reestablishes redox homeostasis through glutathione metabolism modulation, leading to an improved MPI in pulmonary arterial hypertension-provoked right heart failure.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32191845</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1715-5320</ISSN><JournalIssue CitedMedium="Internet"><Volume>45</Volume><Issue>9</Issue><PubDate><Year>2020</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme</Title><ISOAbbreviation>Appl Physiol Nutr Metab</ISOAbbreviation></Journal><ArticleTitle>Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.</ArticleTitle><Pagination><MedlinePgn>987-995</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1139/apnm-2019-0864</ELocationID><Abstract><AbstractText>This study explored the effect of pterostilbene (PTS) complexed with hydroxypropyl-β-cyclodextrin (HPβCD) on right heart function, glutathione and glutaredoxin systems, and the expression of redox-sensitive proteins involved with regulation calcium levels in the experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). After 7 days of PAH induction, rats received daily doses of the PTS:HPβCD complex (corresponding to 25, 50, or 100 mg·kg<sup>-1</sup> of PTS) or vehicle (control group, CTR0) (an aqueous solution containing HPβCD; CTR0 and MCT0 (MCT group that did not receive PTS treatment)) via oral administration for 2 weeks. The results showed that the PTS:HPβCD complex increased the content of reduced glutathione and the activity of glutathione-<i>S</i>-transferase and glutaredoxin in the right ventricle (RV) of MCT-treated rats in a dose-dependent manner. Additionally, at higher doses, it also prevented the reduction of stroke volume and cardiac output, prevented myocardial performance index (MPI) increase, reduced lipoperoxidation, reduced total phospholamban, and increased the expression of sarcoplasmic reticulum calcium ATPase in the RV of MCT-treated rats. These results demonstrate that the PTS:HPβCD complex has a dose-dependent antioxidant mechanism that results in improved cardiac function in experimental right heart failure. Our results open a field of possibilities to PTS administration as new therapeutic approach to conventional therapy for right ventricular dysfunction. <b>Novelty</b> Pterostilbene complexed with hydroxypropyl-β-cyclodextrin could be a new therapeutic approach. Pterostilbene complexed with hydroxypropyl-β-cyclodextrin reestablishes redox homeostasis through glutathione metabolism modulation, leading to an improved MPI in pulmonary arterial hypertension-provoked right heart failure.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lacerda</LastName><ForeName>Denise</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Türck</LastName><ForeName>Patrick</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campos-Carraro</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hickmann</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortiz</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bianchi</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belló-Klein</LastName><ForeName>Adriane</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Castro</LastName><ForeName>Alexandre Luz</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bassani</LastName><ForeName>Valquiria Linck</ForeName><Initials>VL</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Araujo</LastName><ForeName>Alex Sander da Rosa</ForeName><Initials>ASDR</Initials><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Farmacologia e Terapêutica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90050-170, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>19</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>Appl Physiol Nutr Metab</MedlineTA><NlmUniqueID>101264333</NlmUniqueID><ISSNLinking>1715-5312</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">aliments fonctionnels</Keyword><Keyword MajorTopicYN="N">antioxidant</Keyword><Keyword MajorTopicYN="N">antioxydant</Keyword><Keyword MajorTopicYN="N">cardiac contractility</Keyword><Keyword MajorTopicYN="N">contractilité cardiaque</Keyword><Keyword MajorTopicYN="N">cyclodextrines</Keyword><Keyword MajorTopicYN="N">cyclodextrins</Keyword><Keyword MajorTopicYN="N">functional food</Keyword><Keyword MajorTopicYN="N">glutaredoxin</Keyword><Keyword MajorTopicYN="N">glutarédoxine</Keyword><Keyword MajorTopicYN="N">glutathion</Keyword><Keyword MajorTopicYN="N">glutathione</Keyword><Keyword MajorTopicYN="N">insuffisance cardiaque droite</Keyword><Keyword MajorTopicYN="N">monocrotaline</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword><Keyword MajorTopicYN="N">right heart failure</Keyword><Keyword MajorTopicYN="N">stilbene</Keyword><Keyword MajorTopicYN="N">stilbène</Keyword><Keyword MajorTopicYN="N">stress oxydatif</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32191845</ArticleId><ArticleId IdType="doi">10.1139/apnm-2019-0864</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Brésil</li></country><region><li>Rio Grande do Sul</li></region><settlement><li>Porto Alegre</li></settlement><orgName><li>Université fédérale du Rio Grande do Sul</li></orgName></list><tree><country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Lacerda, Denise" sort="Lacerda, Denise" uniqKey="Lacerda D" first="Denise" last="Lacerda">Denise Lacerda</name></region><name sortKey="Araujo, Alex Sander Da Rosa" sort="Araujo, Alex Sander Da Rosa" uniqKey="Araujo A" first="Alex Sander Da Rosa" last="Araujo">Alex Sander Da Rosa Araujo</name><name sortKey="Araujo, Alex Sander Da Rosa" sort="Araujo, Alex Sander Da Rosa" uniqKey="Araujo A" first="Alex Sander Da Rosa" last="Araujo">Alex Sander Da Rosa Araujo</name><name sortKey="Bassani, Valquiria Linck" sort="Bassani, Valquiria Linck" uniqKey="Bassani V" first="Valquiria Linck" last="Bassani">Valquiria Linck Bassani</name><name sortKey="Bell Klein, Adriane" sort="Bell Klein, Adriane" uniqKey="Bell Klein A" first="Adriane" last="Bell Klein">Adriane Bell Klein</name><name sortKey="Bianchi, Sara" sort="Bianchi, Sara" uniqKey="Bianchi S" first="Sara" last="Bianchi">Sara Bianchi</name><name sortKey="Campos Carraro, Cristina" sort="Campos Carraro, Cristina" uniqKey="Campos Carraro C" first="Cristina" last="Campos-Carraro">Cristina Campos-Carraro</name><name sortKey="De Castro, Alexandre Luz" sort="De Castro, Alexandre Luz" uniqKey="De Castro A" first="Alexandre Luz" last="De Castro">Alexandre Luz De Castro</name><name sortKey="Hickmann, Alexandre" sort="Hickmann, Alexandre" uniqKey="Hickmann A" first="Alexandre" last="Hickmann">Alexandre Hickmann</name><name sortKey="Ortiz, Vanessa" sort="Ortiz, Vanessa" uniqKey="Ortiz V" first="Vanessa" last="Ortiz">Vanessa Ortiz</name><name sortKey="Turck, Patrick" sort="Turck, Patrick" uniqKey="Turck P" first="Patrick" last="Türck">Patrick Türck</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/GlutaredoxinV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000029 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000029 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= GlutaredoxinV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:32191845
|texte= Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32191845" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GlutaredoxinV1
| This area was generated with Dilib version V0.6.37. |  |